February 18 – 22, 2019
Naples Beach & Golf Hotel, Naples, FL

An updated review of neurobiology and brain function, will take the attendee through neurotransmission sequence from neurotransmitter synthesis to synaptic function and gene transcription. The clinical usefulness of epigenetic mechanisms will be reviewed, and we will discuss whether there is a role for genetic testing in psychiatric diagnosis as well as  in the selection of specific psychiatric medications. Specific categories of treatment will include: schizophrenia, bipolar disorder, depression, and anxiety spectrum disorders. The evidence-based effectiveness of conventional antipsychotic medications and atypical antipsychotic medications will be emphasized. Newer, useful agents and augmenting medications for the treatment of prodrome and early onset psychotic disorders will be discussed. Bipolar disorder and its treatment will be examined with particular reference to prodrome, early onset illness as well as the diagnosis and treatment of bipolar depression. The use of lithium will be emphasized. A comprehensive review of depression in psychiatric patients, as well as co-morbid with medical illnesses, will be emphasized along with the use of antidepressants of all treatment classes for co-morbid depressions. The role of depression in cardiovascular illness and the necessity for treatment as well as the interaction between endocrine disorders (especially diabetes) and depression will be highlighted. New data regarding the interaction between inflammation and mood disorders will be discussed. An up to date review of ketamine for depression will be emphasized as well strategies for treatment resistant depression. The neurobiological mechanisms of anxiety and anxiety-spectrum disorders, as well as their treatment, will be reviewed, including, panic disorder, social anxiety disorder, post-traumatic stress disorder (PTSD), and generalized anxiety disorder. Problems with uses of all psychiatric medications for the elderly will be discussed with clinical examples.  Data regarding early life traumatic or separation experiences, as precursors to later-life mood disorders, will be introduced.

This master class will also address the neurobiological theories of addiction and their treatment as well as reviewing the neurobiology and potential clinical use of cannabis. Mechanisms of sleep disorders and their effective psychopharmacologic treatment will be detailed as well as the use  psychotropics in women through the course of their lifecycle. The potential usefulness of stimulant medications for adults with ADD, binge eating disorders, and treatment-resistant depression will be noted. The course will emphasize the establishment and importance of therapeutic alliance when prescribing all psychotropic medications. Educational presentation will be in seminar format and include lectures, participant discussions and Q&A. This seminar is designed for the experienced clinician. Course participants will be expected to have had clinical experience, familiarity with the neurobiological and genetic contributions to psychiatric illnesses as well as an understanding of the basic therapeutic mechanisms of psychotropic medications.

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Apply the latest advances in the neurobiology of psychiatric disorders;
  • Determine the role for genetic testing in the selection of specific psychiatric medications;
  • Assess and compare current mechanisms and latest treatment of psychotic disorders, schizophrenia and bipolar illness;
  • Determine when to implement medical switch versus augmentation strategies for treatment-resistant depression;
  • Describe the use of stimulants in adult individuals with psychiatric disorders;
  • Analyze and assess the neurobiological mechanism and evidence-based treatment of antidepressants for anxiety and sleep disorders;
  • Analyze and assess the neurobiological mechanism and evidence-based treatment of benzodiazepines for anxiety and sleep disorders;
  • Review latest findings about inflammation and stress as they apply to the treatment of depression and anxiety-spectrum disorders;
  • Determine the use of ketamine with benefits and hazards in treatment resistant depression;
  • Identify the mechanisms and evidence based treatments of addictive disorders;
  • Review the Neurobiology and potential clinical uses of cannabis;
  • Review the role of psychiatric medications during a women’s life cycle: pregnancy, delivery, post-partum, nursing, and menopause;
  • Update the clinical approach to problems in geriatric psychopharmacology with emphasis on the behavioral and mood disturbance associated with dementia.

Target Audience

The winter seminars are a series of seminars of interest to health professionals in the field of psychiatry, psychology, medicine, surgery, pediatrics, nursing, social work, and counseling.


Monday, February 18, 2019
9:00 am – 12:15 pm
An updated and clinically relevant review of neurobiology as it applies to the etiology and pathology of psychiatric illness, and psychotropic drug treatment effects; the neurobiology of “attachment.”; role for genetic testing. Q&A.
Tuesday, February 19, 2019
9:00 am – 12:15 pm
Biology and treatment of psychotic disorders including schizophrenia, bipolar illness, psychotic depression, and psychosis associated with neurologic conditions; current standards of practice; new uses for atypical antipsychotic drugs; special emphasis on evidence-based treatments of bipolar depression; CATIE study and other recent clinical trials of new antipsychotic drugs; Ketamine; risks and benefits in treatment resistant depression. Q&A.
Wednesday, February 20, 2019
9:00 am – 12:15 pm
Neurobiological mechanisms of depression and its psychopharmacological treatments, including major depression, bipolar depression, and dysthymia; depression associated with medical illnesses, especially cardiovascular and endocrine disorders; treatments of medically related depressions; STAR*D study and other evidenced based clinical trials. Q&A.
Thursday, February 21, 2019
9:00 am – 12:15 pm
Anxiety and anxiety-spectrum disorders; neurobiological mechanisms of anxiety, and the appropriate role of treatments with benzodiazepines, antidepressants, and new approaches; role of anxiety and stress mechanisms as an etiologic factor in psychiatric illness with suggestions for treatment and prevention. Q&A.
Friday, February 22, 2019
9:00 am – 12:15 pm
Treatment of addictive disorders, and eating disorders; medications for depression for women during pregnancy; psychotropic drug treatment of psychiatric disorders common in late life; presentation of interesting/difficult cases from attendee’s practice for discussion and review. Q&A.


CARL SALZMAN, MD is a Professor of Psychiatry, Harvard Medical School, Beth Israel Deaconess Medical Center. He has served as Chairman, American Psychiatric Association Benzodiazepine Task Force. He has been awarded the Elvin V. Semrad Award for Outstanding Teaching in Psychiatry at the Massachusetts Mental Health Center, Vestermark Award from the American Psychiatric Association for Outstanding Contribution to Psychiatric Education, Heinz E. Lehmann Award from the New York State Department of Mental Hygiene for his contribution to psychiatric research, Teacher of the Year Award from CME and Outstanding Psychiatrist of the Year for Education by the Massachusetts Psychiatric Society. He has also been on numerous editorial boards including The American Journal of Psychiatry. Dr. Salzman is author of over 300 publications and 7 books. His latest book is Clinical Geriatric Psychopharmacology, 4th edition.

Other Winter Seminar Courses
Exercise and Other Medical and Complementary Ground Breaking Techniques
for the Treatment of ADHD, Addictions, Social Disorder, Pain, Anorexia, Sleep Disorders, Anxiety, and Mood Disorders

John Ratey, MD

Essential Psychopharmacology, 2019: From Neuroscience to Advances in Treatment
Carl Salzman, MD and Barbara Coffey, MD, MS

Meditation for Everyday Living and Peak Performance for Mental Health,
Medical, and Surgical Practices

Daniel Brown, PhD, ABPH


Physicians: The Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians.

The Harvard Medical School designates this live activity for a maximum of 15.00 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

The Royal College of Physicians and Surgeons of Canada recognizes conferences and workshops held outside of Canada that are developed by a university, academy, hospital, specialty society or college as accredited group learning activities.

Through an agreement between the American Medical Association and the European Union of Medical Specialists, physicians may convert AMA PRA Category 1 Credit™ to an equivalent number of European CME Credits® (ECMECs®). Information on the process of converting AMA PRA Category 1 Credits™ to ECMECs® can be found at:

Psychologists: The Continuing Education Program at Beth Israel Deaconess Medical School, a major teaching hospital of Harvard Medical School, is approved by the American Psychological Association to offer Continuing education for psychologists. The Continuing Education Program at Beth Israel Deaconess Medical School, a major teaching hospital of Harvard Medical School, maintains responsibility for this program and its contents. The Week-long programs offers 15 CE credits.

Counselors: The Continuing Education Program at Beth Israel Deaconess Medical Center, a major teaching hospital of Harvard Medical School, is an NBCC-Approved Continuing Education Provider (ACEPTM) and may offer NBCC-approved clock hours for events that meet NBCC requirements. The ACEPTM solely is responsible for all aspects of the program. The winter seminar programs meet the criteria for 15 clock hours.

Social Workers: This program has been approved for 15 Social Work Continuing Education hours for relicensure, in accordance with 258 CMR. Collaborative of NASW and the Boston College and Simmons Schools of Social Work Authorization Numbers for each course follows:

Exercise and Other Medical and Complementary Ground Breaking Techniques for the Treatment of ADHD, Addictions, Social Disorder, Pain, Anorexia, Sleep Disorders, Anxiety, and Mood Disorders: John Ratey, MD – D72367-3

Essential Psychopharmacology, 2019: From Neuroscience to Advances in Treatment: Carl Salzman, MD and Barbara Coffey, MD, MS – D72367-4

Meditation for Everyday Living and Peak Performance for Mental Health,
Medical, and Surgical Practices:
Daniel Brown, PhD, ABPH – D72367-5

State of New York Social Workers: The Continuing Education Program at Beth Israel Deaconess Medical Center, a major teaching hospital of Harvard Medical School is recognized by the New York State Education Department’s State Board for Social Work as an Approved Provider of continuing education for licensed social workers. 15 contact hours have been approved for these programs.

Nurses: These continuing nursing education activity were approved by ANA Massachusetts, an accredited approver by the American Nurses Credentialing Center's Commission on Accreditation.

ABMS/ACGME Competencies

This course is designed to meet one or more of the following Accreditation Council of Graduate Medical Education competencies:

  • Patient care and Procedural skills
  • Medical knowledge
  • Practice-based learning and improvement
  • Interpersonal and communication skills
  • Professionalism


  Registration Fee
before 12/15/18*
Registration Fee
after 12/15/18*
Physician, Nurse Practitioner, and Allied Health Professionals
Additional weeks $750
$995 $1,075
Residents, Fellows in Training, and Full-time Students $695 $695

*Add processing fee (non-refundable) $10. Registration by credit card (VISA, MasterCard or American Express) or check can be made through Harvard Medical School’s secure online registration system for week 1 or week 2. Registration by check (draft on a United States bank), please make payable to Harvard Medical School. Telephone or fax registration is not accepted. Registration with cash payment is not permitted. Upon receipt of your paid registration, you will receive an email confirmation. Be sure to include an email address that you check frequently. Your email address is used for critical information including registration confirmation, evaluation and certificate. All fees shown in USD.

All course participants will receive a link to a website where they can download the course materials. You can purchase a printed copy at the time of online registration for $35 for Drs. Ratey and Brown’s courses and $50.00 for both of Dr. Salzman’s courses. Please note we will not have hard copies of the syllabus available for purchase at the conference.

By phone 617-384-8600, Monday-Friday, 9 am to 5 pm (EST) or by email at:

Harvard Medical School (HMS) adheres to all ACCME Accreditation Criteria and Policies. It is HMS's policy that those who have influenced the content of a CME activity (e.g. planners, faculty, authors, reviewers and others) disclose all relevant financial relationships with commercial entities so that HMS may identify and resolve any conflicts of interest prior to the activity. These disclosures will be provided in the activity materials along with disclosure of any commercial support received for the activity. Additionally, faculty members have been instructed to disclose any limitations of data and unlabeled or investigational uses of products during their presentations.

Refunds, less an administrative fee of $75, will be issued for all cancellations received two weeks prior to the start of the course. Refund requests must be received by email. No refund will be issued should cancellation occur less than two weeks prior. “No shows” are subject to the full course fee and no refunds will be issued once the conference has started.


Naples Beach & Golf Hotel
The Naples Beach Hotel & Golf Club is an exclusive AAA-four Diamond beach front hotel that is built on a rich tradition of hospitality that began in 1946. Owned and operated by the Watkins family, the Beach Club is Naples’ only beach front resort with a newly reopened spectacular Jack Nicklaus designed golf course on site as well as tennis, spa, and water recreation. The last few years over $50 million has been invested in the resort offering 317-newly remodeled accommodations; new beachside pool complex; retail shopping; restaurants/bars; complimentary Kids Club; and renovated greens & tees. Additional shopping and dining can be found in downtown Naples, just minutes away. The Naples Zoo, Botanical Gardens, and Everglades are other attractions within driving distance.

A limited number of rooms have been reserved at Naples Beach & Golf Hotel. For information and reservations, contact 1.800.237.7600 or the RESORT: Please advise them that you are with the Harvard Medical School Conference. Reservations must be made by January 19, 2019 to reserve a reduced room rate. Reservations made after that date are subject to availability. Please do not purchase non-refundable airline ticket(s) until you have received an email from our office confirming your paid registration.

Last update 9.2.2018