A Comprehensive Update

May 28 – 31, 2014 • Wednesday – Saturday
Fairmont Copley Plaza Hotel
Boston, MA


"Dementia: A Comprehensive Update" is a 3-3.5 day annual review course designed by clinicians for clinicians. The course is organized by Neurology faculty members of Harvard Medical School who specialize in the care of patients with cognitive and behavioral disorders at Massachusetts General Hospital, Brigham and Women's Hospital, McLean Hospital, and ENRM VA Bedford Hospital. The course takes a practical and multidisciplinary approach to understanding and treating dementia and is designed for neurologists, psychiatrists, internists, primary care physicians, geriatricians, psychologists, nurse specialists, social workers, occupational therapists, clinical pharmacists, research scientists, and other health professionals involved in the diagnosis, management, and investigation of disease states causing dementia. This cutting-edge course is in its 18th year, includes local, national and international renowned faculty, and attracts over 400 participants from throughout the U.S. and the world.

The organization of the course takes an integrative approach by interleaving lectures, audience response, and discussions to (1) establish the neuroanatomical and cognitive framework underlying disorders of cognition, (2) address specific diseases (e.g. Alzheimer's disease (AD), Vascular Cognitive Impairment/Dementia, Parkinsonian dementias, Frontotemporal dementias), (3) discuss the latest clinical and research approaches to the diagnosis and treatment of dementing illnesses, and (4) provide, via the main program or optional fee-based programs, additional education on special topics in dementia (e.g. traumatic brain injury, seizures, alcohol, pain, medico-legal issues, capacity, competence, driving, nursing home and end-of-life care).

Three specific programs address the Alzheimer's Disease Clinical Spectrum (Day 1 plenary), Management of Neuropsychiatric and Behavioral Issues in dementia (Day 3 plenary) and Head Injury, Chronic Traumatic Encephalopathy (CTE) & Dementia (Day 3 mini-symposium). Optional fee-based programs include a Day Four ½-day symposium on "From Capacity to Comfort: Legal & Later-stage Long-term Care Issues in Dementia" and two programs on Day Two: "Dementia Screening, Mental Status Exam & Coding in The Primary Care Setting" (Lunch), and "Office Evaluation & Practical Tips For Management of Problem Issues and Behaviors in Dementia" (Clinical Pearls Dinner with Course Faculty).

By the conclusion of the course, participants will be up-to-date on topics in clinical neurology, psychiatry, and psychology and in neuroscience research that bear on present and future approaches to the diagnosis and management of dementia.


Upon completion of this course, participants will be able to: 1.) Describe the clinical functional neuroanatomy underlying the cerebral hemispheres that support perception and cognitive systems including memory, language, frontal/executive, visuo-spatial, and motor systems; 2.) Compare differences due to normal cognitive aging and dementing processes; identify AD risk factors and epidemiology, and distinguish pre-clinical AD, MCI due to AD, and Alzheimer's dementia; 3.) Recognize and differentiate, based on neurobiology and clinical criteria, AD, and its atypical variants, from other common dementias including Dementia with Lewy Bodies (DLB), Vascular-Ischemic Dementias, Frontotemporal Degeneration (FTD), Parkinson's disease with Dementia (PDD), and Parkinson's-Plus Syndromes; identify Chronic Traumatic Encephalopathy (CTE) as a dementia risk/entity; recognize and manage seizures in patients with dementia; 4.) Determine the role of the neuropsychological and mental status exam in the evaluation and management of dementia; identify, interpret and compare typical neuropsychological performance patterns for different dementias such as AD, FTD, and DLB; select and develop efficient approaches to the mental status evaluation and the use of screening instruments (e.g. MOCA) in the evaluation of cognitive impairment and dementia; 5.) Select and utilize appropriate laboratory tests, imaging studies, and neuropsychological testing for the diagnosis of dementia in clinical practice; recognize and incorporate appropriate use of clinical biomarkers (e.g. CSF a-beta/tau, MRI, PET) in the evaluation of neurodegenerative dementias to differentiate AD and non-AD processes; explain the clinical versus research use of AD biomarkers; identify individuals with cerebral amyloidosis and risk of future AD dementia, and evaluate the scientific basis of current and future therapies in clinical trials and research to prevent and treat AD and dementias; 6.) Analyze and apply data-supported pharmacologic management strategies including the roles (i.e., indications and benefits), cautions (i.e., risks, side-effects, warnings) and potential alternatives to using cholinesterase inhibitors, memantine, antipsychotics and antidepressants in dementia and AD; 7.) Recognize, develop and integrate a holistic approach to management of problem behaviors and neuropsychiatric symptoms (e.g. aggression, apathy, anxiety, depression, psychosis) in individuals with dementia that stresses education, and behavioral and non-pharmacological interventions as first-line approaches to care; recognize the importance and implement appropriate psychosocial counseling, genetic counseling, and utilization of community support resources in the care of patients and caregivers; 8.) Recognize, differentiate and develop appropriate practices concerning medico-legal and safety issues surrounding patients with dementia, including capacity with regards to medical care, finances, contracts, independent living, and driving; recommend and integrate medico-legal and safety practices to support and safeguard patients and families with AD and dementias, and the public-at-large; 9.) Describe and implement best practices in the long-term care/nursing-home environment and in end-stage dementia regarding medical, legal, and ethical issues including recognition and treatment of delirium/encephalopathy and pain, providing palliation and hospice care, and managing end-of-life issues related to dementia.


The course involves a multidisciplinary faculty (including cognitive and behavioral neurologists, geriatric psychiatrists, geriatricians, neuropsychologists, and physician-attorneys) and approach to understanding dementia and is designed for neurologists, psychiatrists, internists, primary care physicians, geriatricians, psychologists, nurse specialists, social workers, occupational therapists, research scientists, elder-care attorneys (particularly the Day 4 ½-day optional symposium) and other health professionals involved in the diagnosis, management, and investigation of disease states causing dementia.


The Harvard Medical School is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Harvard Medical School designates this live educational activity for a maximum of 27.25 AMA PRA Category 1 Credits™. Physicians should claim only credit commensurate with the extent of their participation in the activity.

This activity meets the criteria of the Massachusetts Board of Registration in Medicine for 1.5 credits of Risk Management Study. This includes: 1.5 Credits of End-of-Life Care Studies

The Royal College of Physicians and Surgeons of Canada recognizes conferences and workshops held outside of Canada that are developed by a university, academy, hospital, specialty society or college as accredited group learning activities.

AMA PRA Category 1 Credits™ claimed by physicians attending live events certified and organized in the United States for AMA PRA Category 1 Credits™ can be claimed through the agreement on mutual recognition of credits between UEMS and AMA, considered as being equal to the European Continuous Medical Education Credits (ECMEC©) granted by the UEMS. One AMA PRA Category 1 Credit™ is equivalent to one (1) hour of European EACCME Credit (ECMEC©), therefore up to 27.25 ECMEC© Credits are available. Each medical specialist should claim only those hours of credit that he/she actually spent in the educational activity.

This program is sponsored by the Division of Cognitive and Behavioral Neurology and Partners Neurology. The Division of Cognitive and Behavioral Neurology is approved by the American Psychological Association (APA) to sponsor continuing education for psychologists. The Division of Cognitive and Behavioral Neurology maintains responsibility for this program and its content. Depending on participation in optional additional programs, the program offers a maximum of 26 CE credits to psychologists upon successful completion.


8:30-8:40 Directors Welcome and Introductory Remarks
Drs. Atri & Dickerson
8:40-9:25 Overview of Cognitive Functions in Health and Dementia
David Caplan, MD, PhD
9:25-10:05 Memory Systems & Amnesia
Andrew Budson, MD
10:05-10:20 Coffee Break
10:20-11:00 Neuropathology of Dementias: What Practicing Clinicians Need to Know Matthew Frosch, MD, PhD
11:00-11:45 Clinical use of Biomarkers in Dementia: Neuroimaging,
Molecular Studies & Genetics
Bradford Dickerson, MD, MMSc
11:45-12:15 Panel Discussion
AM Faculty
12:15-1:45 Lunch Break
1:45-5:30 Plenary Session:
The Alzheimer's Disease Clinical Spectrum:
Annual Update on Evaluation & Management

Drs. Atri, Doody & Petersen
1:45-2:40 Alzheimer's Dementia: Overview of Evaluation and Care
Alireza Atri, MD, PhD
2:40-3:30 Mild Cognitive Impairment: Updated Criteria, Diagnosis & Care
Ronald Petersen, MD, PhD
3:30-3:45 Coffee Break
3:45-4:35 Pharmacological Therapies in the AD Spectrum:
Standard of Care, Clinical Trials & Future Directions
Rachelle Doody, MD, PhD
4:35-5:30 Panel Discussion
All Faculty
5:30-6:30 Reception with Course Faculty
THURSDAY, MAY 29, 2014
8:30-9:15 Neuropsychology of Aging & Dementia
Sandra Weintraub, PhD
9:15-10:00 Executive Systems & Frontotemporal Dementias
Kirk Daffner, MD
10:00-10:45 Language Dementias: The Primary Progressive Aphasia Spectrum
M.-Marsel Mesulam, MD
10:45-11:00 Coffee Break
11:00-11:45 Apraxia & Motor Programming Disorders in Dementia
Kenneth Heilman, MD
11:45-12:30 Panel Discussion
AM Faculty
12:30-2:00 Lunch Break
12:45-2:00 Nuts & Bolts Lunch and Learn: A Primer on The Mental Status Exam,
Dementia Screening & Coding in the Primary Care Setting

Optional fee-based program, fee $65
Alireza Atri, MD, PhD and Meghan B. Mitchell, PhD
2:00-2:45 Dementia with Lewy Bodies, Parkinson's Disease with Dementia
& Parkinsonian Dementias (CBD, PSP, MSA)
Stephen Gomperts, MD, PhD
2:45-3:25 Can Alzheimer's Disease Dementia Be Prevented?
Prevention Trials in Preclinical AD
Reisa Sperling, MD, MMSc
3:25-3:40 Coffee Break
3:40-4:40 Differential Diagnosis, and Subacute and Rapidly Progressive Dementias Jeremy Schmahmann, MD
4:40-5:30 Panel Discussion
All Faculty
6:30-9:00 Clinical Pearls Dinner with Faculty Program
Optional fee-based program, fee $150
Program: Practical Tips for Evaluation & Management in Dementia:
From Finding the Problem to Problem & Odd Behaviors

6:30 - 7:00 Clinical Pearls Mini-Lectures – Cognitive Impairment:
Detecting the Problem In Your Office
(Dr. Solomon);
Practical Management Tips for Problem- and Odd-Behaviors in Dementia
(Drs. Atri and Dickerson)
7:00 - 7:30 Additional Clinical Pearls From Faculty, Discussion of Cases
and Q&A Discussion
(involving all faculty)
7:30 - 9:00 Dinner at Tables with Faculty
(1-2 faculty per table of participants)
FRIDAY, MAY 30, 2014
8:30-9:15 Vascular Cognitive Impairment & Dementia
Steven M. Greenberg, MD, PhD
9:15-10:30 Mini-Symposium:
Head Injury, Chronic Traumatic Encephalopathy (CTE) & Dementia

9:15 -9:50 The Neuropathology and Neurophysiology of CTE
Ann McKee, MD
9:50-10:30 The Clinical Presentation and Diagnosis of CTE
Robert Stern, PhD
10:30-10:45 Coffee Break
10:45-11:20 Alcohol & Seizures and Dementia
Lauren Moo, MD
11:20-12:00 Panel Discussion
AM Faculty
12:00-1:30 Lunch Break
1:30-5:00 Plenary Session:
Management of Neuropsychiatric and Behavioral Issues in dementia
1:30-2:15 Non-Pharmacological Approaches to Neuropsychiatric Symptoms
and Problem Behaviors in Dementia
Helen Kales, MD
2:15-3:00 Pharmacological Management of Behavioral Problems in Dementia: Psychosis, Agitation & Aggression
Clive Ballard, MDB ChB, MRC Psych, MD
3:00-3:15 Coffee Break
3:15-3:40 Pharmacological Management of Mood, Anxiety,
Apathy & Odd Behaviors in Dementia
James Ellison, MD, MPH
3:40-4:15 The Importance of Caregivers in Dementia: Costs, Benefits,
Burdens and Interventions
James Galvin, MD, MPH
4:15-5:00 Panel Discussion
All Faculty
5:00-5:15 Concluding Comments on 3-Day Portion of the Course
Drs. Atri & Dickerson

SATURDAY, MAY 31, 2014
Optional Half Day Symposium
From Capacity to Comfort: Legal & Later-stage Long-term Care Issues in Dementia
Additional Fee Required for this Optional 1/2 Day Symposium:
$95 for 3-day course registrants, $345 for Symposium Only registrants.

8:30-8:40 Introduction to the Symposium
Drs. Atri, Dickerson & Price
8:40-9:15 Where There's A Will There's A Way: Transactional Capacity in Dementia
Bruce Price, MD
9:15-9:55 Mental Competence and Legal Issues in Dementia
Barry Fogel, MD
9:55-10:30 Defining and Assessing Driving Risk in Older Adults
with Cognitive Impairment: The Clinician Perspective
David Carr, MD
10:30-10:45 Coffee Break
10:45-11:20 Driving & Dementia: Assessment of capacity and Medico-legal Considerations Margaret O'Connor, PhD
11:20-11:50 Legal Issues in Dementia End of Life Care
Rebecca Brendel, MD, JD
11:50-12:30 Management of Behavior, Pain, and Palliative Care in the Long-Term Care/Nursing Home Setting
Sumer Verma, MD, MB
12:30-1:25 Panel Discussion and Q & A
All Faculty
1:25-1:30 Symposium Concluding Comments
Drs. Atri, Dickerson & Price

*Program changes/substitutions may be made without notice.


Course Number #342209

4 Day w/ 1 Lunch and 1 Dinner - Physicians and Doctoral Level Professionals $1,105.00
4 Day w/ 1 Dinner - Physicians and Doctoral Level Professionals $1,040.00
3 Day w/ 1 Lunch and 1 Dinner - Physicians and Doctoral Level Professionals $1,010.00
4 Day w/ 1 Lunch - Physicians and Doctoral Level Professionals $955.00
3 Day w/ 1 Dinner - Physicians and Doctoral Level Professionals $945.00
4 Day Course Only - Physicians and Doctoral Level Professionals $890.00
3 Day w/ 1 Lunch - Physicians and Doctoral Level Professionals $860.00
3 Day Course Only - Physicians and Doctoral Level Professionals $795.00
4 Day w/ 1 Lunch and Dinner - Residents/Fellows and Allied Health Professionals $775.00
4 Day w/ 1 Dinner - Residents/Fellows and Allied Health Professionals $710.00
3 Day w/ 1 Lunch and 1 Dinner - Residents/Fellows and Allied Health Professional $680.00
4 Day w/ 1 Lunch - Residents/Fellows and Allied Health Professionals $625.00
3 Day w/ 1 Dinner - Residents/Fellows and Allied Health Professionals $615.00
4 Day Course Only - Residents/Fellows and Allied Health Professionals $560.00
3 Day w/ 1 Lunch - Residents/Fellows and Allied Health Professionals $530.00
3 Day Course Only - Residents/Fellows and Allied Health Professionals $465.00
1 Day Saturday Symposium $345.00

For specific tuition fees, see the registration form. Registration by credit card (VISA, MasterCard, or American Express) can be made here. Registration by check (draft on a United States bank), please make payable to Harvard Medical School and mail with registration form to Harvard Medical School - Department of Continuing Education, P.O. Box 417476, Boston, MA 02241-7476. Telephone or fax registration is not accepted. Registration with cash payment is not permitted. Upon receipt of your paid registration an email confirmation from the HMS-DCE office will be sent to you. Be sure to include an email address that you check frequently. Your email address is used for critical information including: registration confirmation, evaluation and certificate.


This course is designed to meet one or more of the following Accreditation Council of Graduate Medical Education competencies:

  • Patient care
  • Medical knowledge
  • Practice-based Learning and Improvement
  • Interpersonal and communication skills
  • Professionalism and Systems-based practice


By phone 617-384-8600, Monday–Friday, 10 AM to 4 PM (EST)
or by email


A handling fee of $60 is deducted for cancellation. Refund requests must be received by postal mail, email or fax one week prior to this activity. No refunds will be made thereafter.


Harvard Medical School (HMS) adheres to all ACCME Essential Areas, Standards, and Policies. It is HMS’s policy that those who have influenced the content of a CME activity (e.g. planners, faculty, authors, reviewers and others) disclose all relevant financial relationships with commercial entities so that HMS may identify and resolve any conflicts of interest prior to the activity. These disclosures will be provided in the activity materials along with disclosure of any commercial support received for the activity. Additionally, faculty members have been instructed to disclose any limitations of data and unlabeled or investigational uses of products during their presentations.


All sessions for this course will be held at Fairmont Copley Plaza Hotel, Boston, MA. (Telephone: 1-800-257-7544)


A limited number of rooms have been reserved at the Fairmont Copley Plaza Hotel (Telephone: 617-267-5300 or 800-795-3906) until May 7, 2014. Please specify that you are enrolled in this course to receive a reduced room rate of $320 Moderate & Fairmont Room (Queen bed)/$339 Deluxe Room (Two Doubles or one King bed). Hotel arrangements can also be made online at:

Course #342209

Offered by

Cognitive & Behavioral Neurology, Memory Disorders, and Frontotemporal Disorders Units/Divisions, and MA Alzheimer's Disease Research Center Attending Staff, Harvard Partners Neurology Departments Geriatric Research, Education and Clinical Center Attending Staff, New England GRECC and ENRM Veterans Administration Bedford Medical Center

Course Directors
Alireza Atri, MD, PhD
Bradford C. Dickerson,

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Harvard Faculty

Massachusetts General Hospital

Alireza Atri, MD, PhD

Rebecca W. Brendel, MD, JD

David N. Caplan, MD, PhD

Bradford C. Dickerson, MD, MMSc

Matthew P. Frosch, MD, PhD

Steven M. Greenberg, MD, PhD

Stephen N. Gomperts, MD, PhD

Meghan B. Mitchell, PhD

Lauren R. Moo, MD

Jeremy D. Schmahmann, MD

Brigham & Women's Hospital

Andrew E. Budson, MD

Kirk R. Daffner, MD

Barry S. Fogel, MD

Reisa A. Sperling, MD, MMSc

McLean Hospital

Bruce H. Price, MD

James M. Ellison, MD, MPH

Beth Israel Deaconess
Medical Center

Margaret O'Connor, PhD

Guest Faculty

Clive G. Ballard, MDB ChB, MD
(London, UK)

David B. Carr, MD
(St. Louis, MO)

Rachelle S. Doody, MD, PhD (Houston, TX)

James E. Galvin, MD, MPH
(New York, NY)

Kenneth M. Heilman, MD
(Gainesville, FL)

Helen C. Kales, MD
(Ann Arbor, MI)

Ann C. McKee, MD
(Boston, MA)

M-Marsel Mesulam, MD
(Chicago, IL)

Ronald C. Petersen, MD
(Rochester, MN)

Paul R. Solomon, MD
(Williamstown, MA)

Robert A. Stern, PhD
(Boston, MA)

Sandra Weintraub, PhD
(Chicago, IL)

Sumer D. Verma, MD, MB
(Boston, MA)

  Copyright © 2014, Harvard Medical School, Department of Continuing Education
    Last update 2.28.2014